ZAb_FLEP neutralized a breadth of ZIKV strains and protected mice in distinct in vivo models, including resolving vertical transmission and fetal mortality in infected pregnant mice.
As a future direction for this research, it may be fruitful to incorporate more than one peptide payload onto a single XTEN protein, creating a multivalent "cocktail" therapeutic to which an increased number and breadth of HIV strains is susceptible.
This raised the possibility that broad serum neutralizing activity results from multiple clonal responses each of unique epitope specificity but restricted breadth of viral strain recognition.
To illustrate the breadth of the sampled strains, we mapped 1,970 previously identified marker SNPs from the sixth and seventh pandemic [ 3] to our genomes.
The breadth of different inbred mouse strains that exhibit MLH and inheritance patterns of heterotopia remain unknown.
The efficacy of prepandemic vaccines, which are produced in advance of a pandemic, relies on the vaccine's ability to provide a breadth of protection against different, related strains, as it is not possible to predict exactly the strain that will cause such an outbreak in advance due to the progressive accumulation of antigenic changes.
Sequencing of internal portions of seven housekeeping genes (total 2,976 nt) was performed in 154 A. baumannii strains covering the breadth of known diversity and including representatives of previously recognized international clones, and in 19 representatives of other Acinetobacter species.
Another very important topic for future study is to determine the potential of MN immunization to enhance the breadth of immunity against homologous and heterologous influenza strains.
One of these is to increase the breadth of immunity against new seasonal variants (drift strains), thus reducing the need for annual revaccination.
Genome size of these strains correlates with the breadth of their host ranges.
A refined laminated beam constitutive equation is derived that takes into account the breadth direction strains.
