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Too often popular history has failed to explain the breadth of responses to enslavement.
Also, this was admittedly one of the questions Berkman Community Manager Becca Tabasky asked our Berktern cohort last summer, and I was struck by the breadth of responses!
First, the prevalent and dominant components of the symbiont community cannot explain the breadth of responses of corals to stress or their resilience to locally restricted environmental perturbations, precisely because the dominant components are shared across wide environmental gradients and across reefs with contrasting status.
By increasing the number of Envs within a formulation, we were able to show an increased breadth of responses as well as improved functionality induced in a nonhuman primate model.
The breadth of responses varied across subjects (Fig. 5; Table S3).
The figure shows that over the course of infection, there is a general narrowing of the absolute breadth of responses (Figure 1a).
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However, the increased breadth of response was directed almost entirely against the vaccine strains.
Antigen-specific CTL responses are thought to play a central role in containment of HIV-1 infection, but no consistent correlation has been found between the magnitude and/or breadth of response and viral load changes during disease progression.
Table 3 and Figure 3 demonstrate that EP significantly improves the cellular immune response rate, magnitude, duration, and breadth of response to multiple antigens, consistent with previous results demonstrating the improved effect of EP in animal models and in humans with cancer [33] [35].
Western blot analysis of sera from infected (PCR+ve in blood) and uninfected (PCR−ve in blood) badgers showed a broadly specific IgG response against T. pestanai lysates without exception, with male and female animals showing similar breadth of response (Fig. 4A).
While the total magnitude of the response was not significantly associated with the viral load level (p = 0.088, R = −0.306, Spearman Rank correlation, Figure 4B), we found a significant inverse correlation between the breadth of response and viral load (p = 0.013, R = −0.436, Spearman Rank, Figure 4A).
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