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Results on protective immune correlates and the breadth of protective immunity are presented.
These results indicate that flagellin together with antigen in the same particulate structure functions better as a mucosal adjuvant as shown by the increased breadth of protective immunity.
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These methodologies may both reduce the dose of pDNA required and enhance the breadth and depth of protective immune responses (i.e., humoral and cellular).
To develop a cross protective vaccine, we generated influenza virus-like particles containing the highly conserved M2 protein in a membrane-anchored form (M2 VLPs), and investigated their immunogenicity and breadth of cross protection.
Studies examining medical, psychological, social and economic factors demonstrate the importance of breadth in protective factors [ 21].
CH22 administered to macaques was able to protect against infection with SHIV BaL P4 (Haynes BF and Santra S, personal communication), extending similar work reported earlier (Watkins et al., 2011) and providing new data on the breadth of reactivity and the protective effects of V3 Abs.
After optimization of injection conditions, alternative multivalent DNA vaccine regimens were analyzed and compared for magnitude and breadth of neutralizing antibodies, as well as protective efficacy after challenge in mouse and chicken models of HPAI H5N1 infection.
Loads of protective curves".
Use of protective coatings.
As a result, the set of broadly neutralizing and highly protective antibodies has grown in number, diversity, potency, and breadth of viral recognition and neutralization.
The breadth of the CTL repertoire has been shown to correlate with anti-HIV-protective immunity.
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