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The combination of two mAbs expanded the breadth of protection with a high level of efficacy and safety associated with potential immune escape variants.
To determine whether the breadth of protection afforded by postconditioning extends from the cerebrovasculature to functional outcomes, neurological status was assessed before SAH and daily thereafter via sensorimotor scoring.
The 13-valent pneumococcal conjugate vaccine (PCV13), which contains additional serotypes that are sometimes more prevalent in HIV-infected adults [ 19, 20], may offer a greater breadth of protection than the earlier PCV7.
The efficacy of prepandemic vaccines, which are produced in advance of a pandemic, relies on the vaccine's ability to provide a breadth of protection against different, related strains, as it is not possible to predict exactly the strain that will cause such an outbreak in advance due to the progressive accumulation of antigenic changes.
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In this study, we investigated the generation of VLPs containing the wild type M2 protein as well as their immunogenicity, long-term cross-protective efficacy, and the breadth of cross protection against heterologous and heterosubtypic influenza strains even with a different M2e sequence.
More over, the longevity and breadth of cross protection mediated by M2 immunity remain largely unknown.
To develop a cross protective vaccine, we generated influenza virus-like particles containing the highly conserved M2 protein in a membrane-anchored form (M2 VLPs), and investigated their immunogenicity and breadth of cross protection.
This breadth of vascular protection enhances the translational potential of an isoflurane-based conditioning approach for SAH.
To estimate potential breadth of vaccine protection, serum samples from healthy individuals immunized with the bivalent rLP2086 vaccine were assayed for bactericidal activity using hSBA.
However, these alternatives typically provide compromised breadth and strength of protection.
But lawyers said many questions remained unanswered, including the breadth of the detainees' protections.
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