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What is the breadth of phenotypes that might be influenced by cytoplasmic variation?
However, these studies didn't directly interrogate the interaction of the nuclear and cytoplasmic genomes for quantitative traits or test the breadth of phenotypes affected.
This is almost certainly due to the breadth of phenotypes associated with DAE, combined with the wide variety of potential targets.
With its enormous breadth of phenotypes and sample sizes, PAGE promises to address unanswered questions regarding the epidemiologic architecture of GWAS-identified variants, gene-gene and gene-environment interactions, pleiotropic variants, and intermediate phenotypes to help elucidate their function.
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The breadth of phenotype data available in each PAGE data set permits hundreds of phenotypes to be tested against each genotyped SNP in a "phenome-wide association study".
In many respects, a general survey of gene expression phenotypes serves as a proxy for the nature and breadth of phenotypic variation in human cancer [ 2, 3].
In order to examine the breadth of tumor phenotypes promoted by this prolonged PRL exposure, we examined a panel of 39 of these tumors (mean latency +/- standard deviation (S.D ., 18.2+/-3.6 months).
Limitations set by galling behaviour of pollinating fig wasps might have consequences for the breadth of host phenotypes that can be used for reproduction and between which pollen is transferred.
Since the breadth of the phenotypes attributable to tra1 -F3744A suggests that SAGA function is altered, we propose that the lack of change in histone H3 acetylation is due to the ability of the Ada complex (Eberharter et al. 1999), including Gcn5, Ada2, and Ngg1, to act independently of SAGA.
To our knowledge, there have been no published reports describing the breadth of the phenotype associated with mutations in NRXN1.
To assess the breadth of this phenotype we assessed the impact of IFNα treatment on the infectivity of pseudoparticles expressing a panel of genotype 1 HCV glycoproteins.
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