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Breadth of gene expression was estimated as the number of organ and tissue sources of gene-specific ESTs.
Similar to Ka values, K3' values inversely correlated with breadth of gene expression (R = −0.11, p<0.01).
In addition, we provide evidence that the level and the breadth of gene expression are related in opposite ways to many structural parameters of gene sequences.
The considered regional variables only partially accounted for the relationships between the level and breadth of gene expression and gene sequences.
We show that architecture of regulatory PK genes significantly differs from other protein coding genes and explore relationships between gene structure, evolutionary conservation, transcript levels and breadth of gene expression.
The level of non-synonymous substitutions in PK genes negatively correlated with breadth of gene expression (R = −0.82, p = 1.73×10−9, Figure 3A), which is consistent with a general trend for non-PK genes and correlations observed in protein coding regions of non-regulatory genes [26], [27].
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What factors determine the levels and breadths of gene expression?
We identified several key genomic traits whose relative effects on levels and breadths of gene expression are quantified.
Secondly, in all significant predictors, the signs of coefficients are the same for both levels and breadths of gene expression.
Here, we show that we can predict substantial amount of variation in levels and breadths of gene expression using genomic information of each gene.
> -wrap-foot> > -wrap-foot> Our multivariate models explain between 7 and 14% of total variation in levels and breadths of gene expression (Tables 2 and 3).
More suggestions(12)
spectrum of gene expression
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scope of gene expression
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amplitude of gene expression
range of gene expression
extent of gene expression
magnitude of gene expression
breadth of gene metabolite
breadth of gene space
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