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Using a collection of expressed sequence tag (EST) data, Zhu et al. investigated the breadth of expression for 17,288 human RefSeq loci across 18 human tissues.
We computed the breadth of expression for each gene in each lineage as the total number of different stages in which a gene is expressed.
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We also find no evidence for a stronger similarity in the breadth of expression of the linked ligands and receptors than those on different chromosomes.
It is fashionable to belittle Vivaldi these days, but perhaps we should listen to him as we would the best of rock-and-roll, looking not for harmonic sophistication or breadth of expression but for the honesty of emotion and the capacity to exhilarate.
Linked genes are of no more similar breadth of expression (mean difference for linked genes 0.75 +/- 0.12, for unlinked 0.686 +/- 0.036, t-test, P = 0.58).
However, when breadth of expression is concerned, for eight of the 16 amino acids studied (Ala, Gln, Gly, Ile, Leu4, Pro, Ser4, Thr) their RMCU is in positive correlation with breadth of expression, as expected by the translation selection model.
Figure 2 contains bar graphs describing the relation between breadth of expression and RMCU for the amino acids in Group B. We look to see whether this partition into Groups A and B is related to other amino acid attributes.
Figure 1 contains bar graphs describing the relation between breadth of expression and RMCU for the amino acids in Group A. (It is evident from Table 1 that for 7 out of the 8 amino acids from group A, the RSCU of the major codon is in positive relation with breath of expression).
Controlling for breadth of expression makes no difference to this conclusion [see Additional file 6].
No reasons are given as to why microarray and EST datasets differ in their results for breadth of expression.
The reason for the breadth of expression being more tightly correlated with the rate of evolution than the abundance of expression in multicellular organisms is not entirely clear.
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