The rate of synonymous substitutions increases with the breadth of expression: proteins expressed in a larger number of stages evolve at higher rates at synonymous sites.
2) Do genes with distinct breadth of expression (number of tissues where a gene is expressed) show a correlation with certain structural genomic features in chicken? 3) Are the expression patterns of orthologous genes conserved among species?
Nested genes are expressed in significantly fewer tissues (have narrower breadth of expression) than either including genes or control genes (table 2).
Using a collection of expressed sequence tag (EST) data, Zhu et al. investigated the breadth of expression for 17,288 human RefSeq loci across 18 human tissues.
We analyzed structural features of PK genes associated with breadth of expression (defined as the number of tissues where a gene is expressed).
While there has been some success in predicting the breadth of expression (i.e., the fraction of tissue types a gene is expressed in), predicting tissue specificity remains challenging.
Additionally, the previous study established an association between the evolutionary rate of genes and the breadth of expression, i.e. the number of tissues in which a gene is expressed.
The Sonata in A (Op. 69), from his heroic middle period, bracingly mixes Olympian breadth of expression and restless ingenuity.
Mr. Barenboim is at his best in scores like this one, which shift from spans of magisterial music requiring great breadth of expression to impetuous bursts of action and intensity.
The broad-based expression of the HCG promoters is not a consequence of a correlation with CpG content because within the HCG class the breadth of expression is independent of the CpG content.
Here we exploited the breadth of expression data sets from the Immunological Genome Project to analyze how the differentiation of thymic precursors gives rise to mature T cell transcriptomes.
