The advantage of this approach is that platelets, lymphocytes and monocytes can act as differential sensors or biomarkers of mitochondrial dysfunction in different pathologies, thus increasing the breadth and diagnostic versatility of the BHI.
However, the utility of diagnostic NGS is highly dependent on the breadth and quality of databases that contain whole-genome sequence information of reference strains needed for alignment [ 19].
Their applications cover the full breadth of the clinical spectrum from enhancing diagnostic imaging to photothermal and photodynamic therapy, drug delivery, and radiosensitization [1, 2].
It could therefore be of value to a wide range of people – those in training, researchers wanting a breadth of information, pathologists – but not necessarily those wanting to solve that diagnostic problem.
This review considers the breadth of the published literature and explores the possibilities, advantages, and limitations for implementation of PCR-ESI/MS in diagnostic laboratories.
The overall breadth of prostate cancer and problems associated with it render it necessary to develop novel therapeutics and diagnostics for the disease.
In one sense, the breadth of our study population could be perceived as a limitation, though the inclusion of all inpatients across all diagnostic categories is also a strength as it reflects real-world clinical practice.
Given the breadth of our search strategy, we feel that we are likely to have captured the majority of validations of GPRD diagnostic data published in the specified time period.
The breadth of opposition is hardly surprising.
