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A possibility for improving the SPME technique is to use replicate samples with additional fiber types to better capture and characterize the breadth of compounds present.
Instruments are mature enough to run large sequences of samples; novel advancements increase the breadth of compounds that can be analyzed, and improved algorithms and databases are employed to capture and utilize biologically relevant information.
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However, the challenges associated with the quantitative and qualitative analysis of complex VOC mixtures in an aqueous solution are non-trivial, and neither method had the ability to both identify and quantify the breadth of compound diversity synthesized by this complex fungal system.
In a twenty-year period, and despite the increasing breadth of activity of individual compounds, the percentage of patients receiving combinations of antibiotics, as opposed to single antibiotic administration, increased from 23%to44%4% [ 2].
These compounds showed noticeable breadth of antiviral potency with IC50 of as low as 150 nM.
(B ) Frequency distribution of compounds from the >240K library within the top 15% distance from highest active plotted to generate predicted breadth of tuning curves.
At a time of growing debate over the safety and usefulness of flame retardants added to consumer products, new evidence is emerging about the breadth of human exposure to one of the most widely used of these compounds.
In contrast, biophysical fragment screening of wild-type GPCRs retain the full breadth of pharmacology in measuring agonists and antagonists and thus provide the opportunity for discovering compounds with diverse mechanisms and potentially novel binding sites.
The breadth of this network reflects the complexity of each trial, requiring motor responses based on judgements of compound visual stimuli according to spatial and lexical information.
The breadth of opposition is hardly surprising.
Such is his breadth of view, his breadth of vision, his breadth of influence.
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