Sentence examples for breadth of cellular from inspiring English sources

Similarly, for HDFs we found this signal significantly reinforced (P<0.01) as well, confirming that the use of a small subset of host proteins effectively secures a pathogen's reach into a breadth of cellular activities without inundating any particular one.

Because of this wide breadth of cellular mechanisms involved in nuclear localization, it should always be considered an aspect of therapeutic intervention.

In this respect, optimizing biosynthetic productivity will almost certainly benefit from computational modeling tools that systematically and efficiently explore the consequences of gene- or enzyme-level modifications across the breadth of cellular metabolism.

Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.

Furthermore, we showed that insertion of C7L in NYVAC-B genome clearly improves the magnitude and breadth of the cellular immune response induced against the HIV-1 antigens as compared to NYVAC-B.

Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus, since CD8+ T cells recognize epitopes of eight to 11 amino acids in length and the infecting virus sequence is usually significantly different from consensus sequences.

Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment.

In the cellular immune response this exchange governs the magnitude and breadth of killing of cellular targets, inflammation or tolerance.

This is the first demonstration in healthy volunteers that EP is safe, tolerable, and effective in improving the magnitude, breadth and durability of cellular immune responses to a DNA vaccine candidate.

Indeed, two recent studies demonstrated that mosaic HIV-1 vaccines increased the breadth and depth of cellular immune responses in Rhesus monkeys [15], [16], especially in the case of bivalent mosaic HIV-1-B Gag, Pol and Env antigens expressed by recombinant adenovirus serotype 26 vectors [15].

Mosaic HIV-1 immunogens have shown increased breadth and depth of cellular immune responses compared with those of consensus or natural sequences in monkeys (7, 11).