For example, platelet-derived growth factor promotes the proliferation of glioblastoma cells through downregulation of miR-21 [ 12]; the breadth of actions of such an agent is apparent from the observation that it can also enhance glycosaminoglycan elongation on the proteoglycan biglycan and thereby plays a role in the initiation of atherosclerosis [ 13].
The true measure of OGP's success is not the height of our aspirations, but the depth and breadth of our action.
Lawmakers should consider the breadth of this action and the degree to which it may create additional obstacles for placing needy children with good parents in a state that already has one of the lowest rates of such placements.
A significant, but poorly understood feature of their field effectiveness is their breadth of toxic action which includes direct lethality, excitant-repellant behavioral effects, and chemosterilization.
Although the predominant focus of the field has been on outlining the breadth of possible action-game-related enhancements, recent work has concentrated on uncovering the mechanisms that underlie these changes, an important first step towards the goal of designing and using video games for more definite purposes.
Furthermore, the name does not acknowledge the breadth of BMP actions, and it is still not clear what controls and how a specific BMP will be osteoinductive.
Indeed, we have just started to comprehend the breadth of their actions in changing gene expression in normal and abnormal states.
"While Manchester United are clearly always an attractive proposition because of the audience they attract, the scope of our coverage encompasses the full breadth of FA Cup action," an ITV spokesman said.
Morals are not dependent on breadth of sexual activity.
