These findings demonstrate the remarkable breadth of functions that underpin ER homeostatic functions in this organism.
This conception resulted from the breadth of functions attributed to the patron deity of a Greek state: a city goddess must be chief in peace and war alike.
Together, these findings define a core set of mRNAs subject to translational control during the adaptive response to acute ER stress in A. fumigatus and reveal a remarkable breadth of functions that are needed to resolve ER stress in this organism.
If PEPCK's genotypes do differ in function, they could, for example, increase heterozygotes' breadth of function across the range of a state variable such as temperature, or differ in balances of alternate metabolic roles (below).
The present study is the first to show that GM-CSF can function as a strong mucosal adjuvant when co-administered to the skin with an influenza DNA vaccine enhancing both the frequency of mucosal antibody detected in the lung and the magnitude, breadth, and function of T cell responses in the lung and gut.
This trend remains significant when potential confounding factors (gene expression level and breadth, duplicability, function, and length of the encoded products) are controlled for.
We specifically address the phenotype, function, longevity, epitope breadth, and functional avidity of the vaccine-elicited immune response in order to better characterize the protective potential of a DNA prime, rAd5 boost vaccine regimen.
Recent research in the nematode Caenorhabditis elegans has expanded the breadth of RNAi functions to include transgenerational epigenetic memory and, possibly, environmental sensing.
Identifying the total number of target sites, especially for those low-abundance and species-specific miRNAs, is helpful for appreciating the breadth of miRNA functions [ 27].
Investigating the full breadth of Lhx3/4 functions in multiple ascidian species will be required in order to determine the relationship between Lhx3/4 duplication and re-wiring of Mesp regulation.
