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Due to this relationship between REFERs and transition-state structure, the sensitivity of the REFER slope to mutation-induced energetic perturbations allows estimation of the breadth of the energy landscape underlying gating.
The limited size and breadth of typical experimental data sets do not permit estimation of all of the physiological parameters of complex mechanistic models; often because many of the PD markers needed to describe the system are lacking and/or the number of samples collected over time too few.
Using an algorithm based on the breadth-first search (BFS), an unobservable topology attack on AC state estimation was developed [13].
The loss of the trends in the two histone marks may partly be due to the breadth of those signals often spanning the entire genic regions, thus introducing error in estimation of precise proportions of those signals, which can overwhelm real signals in a relatively small dataset.
You need breadth.
A mere hair's breadth.
Where's the breadth?
Polish, understatement, breadth.
Breadth Requirement.
Estimation of transposon coverages.
"It is an estimation.
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