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Second, we found that novel NTRs showed narrow tissue breadth compared with annotated genes, as shown by the T value which scores a value between 0 for housekeeping genes and 1 for tissue-specific genes [ 23].
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Mice vaccinated with the linked TLR agonists showed an increase in antibody depth and breadth compared to mice vaccinated with the unconjugated mixture.
For one immunogen, the neutralizing response was increased with a higher breadth compared to the Wild-Type.
The vessels of female mice had an increased breadth (P=0.018) compared with male mice.
However, when the fraction of emerging and reemerging species is compared with the breadth of host range (as the number of host types other than humans), a pattern becomes apparent.
Notably, measured bioaccumulation data are quite limited compared with the breadth of the chemicals currently used in commerce, as studies have historically focused on the approximately 100 known persistent organic contaminants.
The OA-FUNCTION-CAT provided superior reliability throughout the score range and improved breadth and precision at the ceiling compared with the WOMAC.
This agrees with the observation that housekeeping genes in mice and human evolve more slowly than tissue-specific genes (Zhang and Li 2004), which can also be associated with the increased breadth of expression of such genes compared with tissue-specific genes (Park and Choi 2010).
The alignment pipeline used in PolyPhen-2 selects homologous sequences using a clustering algorithm and then constructs and refines the alignment yielding an alignment containing both orthologs and paralogs that may or may not be full length, which yields a wider breadth of sequences but decreased depth compared with the curated alignments used with Align-GVGD and SIFT [ 36].
Mosaic HIV-1 immunogens have shown increased breadth and depth of cellular immune responses compared with those of consensus or natural sequences in monkeys (7, 11).
The above observations implied that microarray data on average detected less number of genes compared with EST data, thus underestimated the expression breadth, making the expression breadth distribution in microarray data skewed toward TS genes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com