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Under the genomic design view, due to the positive association between the breadth and rate of gene expression, genes that are constitutively expressed at a high level and do not require complex regulation possess shorter introns [ 160].
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In addition, we assess correlations between rates of protein evolution and genomic factors such as gene expression level and breadth, recombination rate, and GC content in order to understand what genomic factors underlie the variation in rates of protein evolution in Arabidopsis.
In comparison, in primates, expression breadths and synonymous rates exhibit significant relations.
Analysis of the expression breadth across the tissues also showed a significant negative correlation between the breadth and the lincRNA evolutionary rates although the typical correlation coefficients (0.04 0.12) were smaller compared with the median of expression and EST counts (results not shown).
In order to visibly corroborate the association of bimodal distribution with structural variations, we applied principal component analysis using XSTAT to gene subgroups of low and high GC content with intron size, intron number, evolutionary rate, expression breadth and level as variables.
This pattern is very pronounced: for instance, the correlation coefficient between one of the measures of the phylogenetic breadth and depth (LS) and the rate of protein evolution between humans and chimps (Ka or Ka/KS) is higher than 0.5.
Better data are needed to establish the relative importance of the breadth and level of expression in determining evolutionary rates in passerines.
One interesting species-specific difference is the relationship between gene expression breadths and synonymous evolutionary rates.
We interestingly obtained that network perturbations, tissue expression breadth, and gene functionality have substantial contributions to the evolutionary rate variations of SHD, SPD, and ND genes.
Please rate the findings of the study in terms of their breadth and depth.
"They have such dynamic breadth and coloration.
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