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Significantly, viruses that had shorter V1 V4 loops induced antibodies that showed more neutralization breadth against the subtype C panel viruses (p = 0.0135).
Immunizations yielded little neutralization against wild-type viruses but potent CD4-supersite neutralization (titers 1: >1,000,000 against four-glycan-deleted autologous viruses with over 90% breadth against four-glycan-deleted heterologous strains exhibiting tier 2 neutralization character).
Of these, 37 neutralized at least one of the isolates tested and 3 mAbs in particular bound to the CD4bs, V3 crown and HR-1, showing considerable neutralizing breadth against a panel of HIV-1 pseudoviruses of different clades and spanning Tier-1 and Tier-2 isolates.
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The handlebars were so wide and keeping me so upright that on my first couple of trial rides, I felt like a sailboat sail, my body's breadth working against me.
However, for all total length variables and for all threshold values, the segmented regression against breadth explained less variance than the segmented regression against expression level (supplementary fig. S9, table S3, Supplementary Material online).
Though their treatment is comparable, the two men come from radically different backgrounds, and this illustrates the breadth of dissent against the Egyptian government.
But new research pitting the lyrical breadth of Bob Dylan against some of today's most successful rap artists suggests the times they are a-changing.
Even so, when the final settlement was signed on April 28th, the breadth of evidence against the banks, and the language used to describe what they got up to, made for shocking reading.
Both CD4i Abs identified here demonstrated strong cross-clade breadth with activity against 10 of 11 envelopes tested, including those from clades A, B, C, A/D and C/D, whereas the V3-specific antibody showed more limited breadth.
Another very important topic for future study is to determine the potential of MN immunization to enhance the breadth of immunity against homologous and heterologous influenza strains.
One of these is to increase the breadth of immunity against new seasonal variants (drift strains), thus reducing the need for annual revaccination.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com