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In wildtype mice, branching morphogenesis within the mammary gland occurs from birth to sexual maturity.
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Neuroepithelial, ciliated, and finally non-ciliated secretory Clara cells differentiate within the airway buds that undergo branching morphogenesis during the pseudoglandular stage (∼E10.5 E16.5), while more-distally located alveolar epithelial cells (AECs) begin to differentiate later during the canalicular stage (E16.5 E17.5).
During lung branching morphogenesis the airways develop together with the vasculature and smooth muscles.
Concurrent with branching morphogenesis, the cells undergo cytodifferentiation to produce the multiple epithelial subtypes required for adult organ function.
Sprouty negatively modulates branching morphogenesis in the Drosophila tracheal system.
3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung.
Title 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung.
Recent computational models of branching morphogenesis in the lung have helped uncover the biological mechanisms that construct this ramified architecture.
Dean, C., Ito, M., Makarenkova, H. P., Faber, S. C. & Lang, R. A. Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation.
During the embryonic stage, the lung bud separates from the gut followed by the branching morphogenesis in the pseudoglandular stage until 17 weeks of gestation.
During the branching morphogenesis program, the distal epithelial progenitors give rise to several differentiated epithelial cell types of the conducting airway [5].
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