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The development of the mammary gland, unlike that of other human organs, is completed only postnatally when, in response to ovarian hormones (estrogen and progesterone), extensive TDLU proliferation occurs, resulting in branch extension into the surrounding stroma and lobule differentiation.
Activation of endogenous RhoA decreased branch extension without affecting branch additions and retractions, whereas dominant-negative RhoA increased branch extension.
The interplay between these two signals, reconstructed across four time points, suggests that F-actin polymerization promotes branch extension.
Branch initiation was controlled by signaling through p38 mitogen-activated protein kinase, whereas branch extension was controlled by Smad-mediated induction of a second diffusible inhibitor, Wnt5a.
(a) New branch extensions, including both terminal and interstitial branching: -1; (b) local scaling in branch length (stretching/contracting) or radius (thickening/thinning): -2; (c) branch rotation or deformation: -3; (d) terminal branch retraction: -4; and (e) branch re-emergence (a special case of branch extension following a retraction at the same location): -5.
First-hand accounts, such as the one by F. A. Wagner superintendent of the Branch Extension Station in Garden City, Kansas capture the region's plight: "The Drought of 1934..
Similar(43)
The extensive branching reported in kif2a−/− and Map1b−/− neurons was suggested to be partly due to an impaired suppression of collateral branches extension [34], [36].
In a third type of assay, we showed of these cells to form branching extension in a 3D collagen lattice.
It is likely that the developmental and regeneration processes that govern LTMR lanceolate ending branching, extension, orientation, size, and TSC association have common mechanisms.
This stain enabled him to demonstrate the existence of a kind of nerve cell (which came to be known as the Golgi cell) possessing many short, branching extensions (dendrites) and serving to connect several other nerve cells.
3.1 to a hypothetical but still realistic— branch-extension of a large furniture store company in Germany.
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