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Projections of the amygdala to brainstem areas such as the LC were proposed as instrumental in the detection of and orienting to visceral signals of emotions [13].
Aside the superficial RTN/pFRG chemoreceptors, several groups of chemoreceptors are described in discrete brainstem areas, such as the pontine catecholaminergic A5 and A6 areas, the ventrolateral medulla and the raphe areas [33], [35].
Gap junction coupling occurs between cultured chemoreceptors [43] as well as between chemoreceptors of discrete brainstem areas such as the locus coeruleus [44], the raphe [45] and the RTN/pFRG [46].
The major inputs to the lateral habenula (Hb) project from the limbic system and basal ganglia motor areas, as well as brainstem areas such as the median raphe and ventral tegmental area (VTA).
In addition, there are several brainstem areas, such as the raphe pallidus (RPa) and inferior olive (IO), two nuclei which have been functionally linked to the regulation of BAT thermogenesis (240, 243– 246), where VMH neurons have been postulated to relay to modulate SNS activity (2, 127, 241).
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Most were located in the deep brain areas, such as the brainstem, thalamus, and cerebellum, and were not analyzed in detail.
Although gross total resection of the tumour is often curative, location in critical or deep areas (such as the brainstem and hypothalamus) can render it unresectable and require additional management approaches.
However, in some cases, significant disability can occur in the presence of a small number of lesions if they are located in areas such as the brainstem and spinal cord [3].
Because most of the data on tau-positive deposits summarized in Table 2 and Fig. 3 have been obtained on cerebral cortices, it remains to be determined whether these findings are similarly applicable to extracortical areas such as the brainstem.
The present study has shown that EPs are useful in localizing changes in meditation to areas such as the brainstem, thalamus, thalamocortical radiations, primary sensory cortices, and association cortical areas and ERPs can provide useful information about neurocognitive processing of attention and brain resource allocation.
Fractalkine transcript expression has been reported to be significantly lower in the cerebellum and other caudal areas such as the brainstem than the hippocampus or striatum, which may help to explain the rostral caudal gradient of microglial phenotype changes (Tarozzo et al., 2003).
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