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Changes in p62 mRNA levels, determined in a primate model (SIVE and uninfected brains) and neuronal p62 protein distribution and content, detected by immunohistochemistry in monkey brain tissues and HAD brains, support the in vivo relevance of these findings.
Notably, studies using human brains support the involvement of cytoplasmic superoxide radicals in AD pathology.
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Both CRYAB and TNFAIP1 show increased transcript levels in AD brains, supporting the validity of this approach.
As expected, both Amfutsch and Amtau were expressed in the developing pupal brains (Supporting Information S1, Fig. S5 and S6).
These two independent studies establish that aberrant levels of both proteins (OMI and HSPA8) occur in PD brains, supporting our results that show the relationship between them.
Studies on human postmortem brains supported over-expression of the XIST gene in female psychiatric patients.
- Candidate gene analyses also showed differential DNA methylation and expression between human and non-human primate brains,, supporting a role for human-specific DNA methylation in brain evolution.
Plus Brain Support Network helps LBD group members donate a loved one's brain for research.
Findings from a 2017 investigation published in the journal Brain support the idea that amyloid and tau must interact to cause AD.
In the brain, a network of regions, including certain sections of the prefrontal and parietal cortex (at the front and top surface of the brain), support voluntary or top-down selective attention.
By complementing our in vivo work with detailed analysis of synaptic connectivity and network dynamics in vitro, we hope to arrive at a more complete understanding for how neural circuits in our brain support sensation, cognition, and action.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com