Naproxen showed the lowest concentrations within the brain in comparison to the plasma levels but did reach effective doses [38].
In contrast, Peg11 was undetectable in PMEFs and was expressed at lower levels in the brain in comparison to its antisense transcript.
These data suggest fundamental differences in the requirement for IL-1 in regulating a key component of innate immune responses in the brain in comparison to extracerebral tissues.
To our knowledge, this is the first unequivocal demonstration that IL-1 controls neutrophilic inflammation differently in the brain in comparison to systemic tissues.
Interestingly, human ApoE4 carrying transgenic mice presented the highest sulfatide depletion in the brain in comparison to wildtype ApoE or human ApoE3 transgenic mice [ 181].
In addition, APAF-1, caspase-3 and -9, and the pro-apoptosis Bcl-2 family member Bim are present in higher concentrations in developing neonatal brain in comparison to adult brain tissue [ 82, 83].
In this study, we used two screening tools, namely the DT and the HADS to evaluate the course of psychological burden in patients with BM and RT to the brain in comparison to a CG of breast cancer patients.
As previously reported (27), we found that Idua −/− mice displayed increased levels of GAG storage in peripheral organs and in different sections of the brain in comparison to unaffected heterozygous animals.
Among patients with detectable levels of hTERT mRNA, the amount of hTERT transcripts was significantly higher among glioblastoma patients as well as patients with metastatic tumours to the brain in comparison to patients with other tumour histotypes (data not shown).
In the normal white matter of the human brain, a low number of iNOS-positive microglia cells is present (Marik et al., 2007), which may reflect some basic activation of microglia in the human brain in comparison to animals, housed under specific pathogen-free conditions.
