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Vitamin E and vitamin C administration in fipronil exposed mice also improved histological architecture of the kidney and brain when compared with fipronil alone treated groups.
Accumulation of Fl significantly (p < 0.05) increased in the Fl-treated brain when compared with control rats.
In young PDAPP/TRE4 mice that were analyzed at an age before brain Abeta deposition, we observed a significant decrease in the levels of apoE in CSF and brain when compared with age-matched mice expressing either human E2 or E3.
Tissues treated with Bio-ZnONPs (i/v route: dosage range 11-16 μg/kg, i/p route: dosage range 24-30 μg/kg) showed no changes in the liver, kidney, spleen and brain when compared with control tissues (Figs. 4, 5, 6 and 7).
Both PBS -and berberine-treated EAE mice showed a significant increase in the content of EB in the brain when compared with the control mice (P<0.01).
In both tgWT and tgMT mice, BiP expression was increased in the spinal cord, but unaltered in the brain when compared with control mice.
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They found the brains of females with autism "look" more like - but still not the same as - typical male brains, when compared with the brains of females without autism.
In addition, up-regulated APP-BP1 expression has been observed in the lipid rafts in the hippocampi of AD brains, when compared with age-matched control brains [22].
Previous studies have reported that 5-LO immunoreactivity is increased in hippocampi of AD patients, and that its protein levels are higher in cortex and hippocampus, but not cerebellum, of AD brains when compared with healthy controls [10], [11].
The possibility of L1 expression and retrotransposition in human neural progenitor cells is suggested by the increased copy number of endogenous L1s in adult brains when compared with heart and liver samples obtained from the same individuals [ 149].
A causal role of Bax was not pursued in the present study because Bax −/− mice displayed grossly enlarged brain volume and brain weight when compared with wt littermates (Supplementary Figures 1c and d).
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