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It showed significantly higher transnasal permeation and better distribution to the brain, when compared to the used control (drug solution and/or suspension).
It showed significantly higher transnasal permeation and better distribution to the brain, when compared to the used control regarding the brain targeting efficiency and the drug transport percentage (2.16 and 1.43 folds increase, respectively).
Results from the in vivo distribution study indicated that 1a 1c, and 1b in particular, significantly increased the level of naproxen in brain when compared to 2 and 3.
In contrast to these studies, we did not find a significant effect of treatment aimed at improving the flow state of the brain when compared to control patients in a randomised design.
We found that the levels of both Aβ1−40 and Aβ1−42 were significantly reduced in both the soluble and insoluble factions of Lenti-NIa-infused brain when compared to the Lenti-GFP-infused brain (Fig. 7A).
While brain APP is metabolized rapidly in both wild-type and an APP transgenic mice, our findings unexpectedly show that sAPP is more stable in vivo in the β-amyloid containing Tg2576 brain when compared to wild-type mice.
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In these experiments, mRNA levels of both BDNF and NT3 were markedly down-regulated in virus-infected neonatal brains when compared to control mice (Fig. 8).
We found PIK3C3 and, consistent with our previously published findings [41], BECN1 to be strongly reduced in AD brains when compared to non-demented age-matched controls (Fig. 7B C).
Quantification of total NCX1 protein as a proportion of NSE revealed no significant alterations in NCX1 in any of the neurodegenerative disease brains when compared to controls.
B) Grb10 m/+ and Grb10 m/+ /Dlk1 +/p mice had overgrown brains when compared to wild type and Dlk1 +/p animals.
Main text: "We found a smaller but significant reduction could also still be found even if these 'local' principal components (i.e. from the same brain region) were orthogonalised with respect to those of another, simultaneously recorded brain region, when compared to performing the same analysis in reverse".
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