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Ze et al. [68] treated mice with three doses of TiO2 NPs nasally for 90 days and found that the levels of superoxide (O2 −), H2O2, MDA, protein carbonyls, and 8-hydroxy-2′-deoxyguanosine in the mouse brain were increased in all groups compared with control animals.
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VEGF expression in the brain was increased in European travellers who died of CM compared to controls with non-neurological causes of death [44], and plasma VEGF levels positively correlated with neurological complications in African children with CM [45].
The area under the curve (AUC) in serum and the brain was increased in cyclosporine cotreated rats.
Activity of reward systems in the brain is increased in the fasted state compared to the fed state with presentation of food-relevant stimuli (LaBar et al., 2001).
SP1-DNA interaction and APP expression in mouse brains are increased in a latent fashion by early-life dietary administration of Pb [ 29].
In the KIDutch model, Fmr1 mRNA levels in brain were increased threefold over WT (Willemsen et al., 2003).
However, bone marrow-derived microglia in the brain were increased by the treatment.
The early onset brain tumours were increased in offspring of affected parents (4.79) and in siblings (6.06).
Brain pimonidazole concentrations were increased in restrained mice (sham and LTH treatments) compared to unrestrained controls, but average brain/plasma ratios were similar in all three groups at between 400 and 500%.
These data suggest that autophagic flux in brain is increased after exercise in wild-type mice but not in BCL2 AAA mice.
For both measures of brain injury, the rates were increased in patients with hypothermia and hyperthermia compared to normal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com