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Statistical significances of changes in circulating bone marrow stem cells, bone marrow-derived cells, bone marrow-derived microglial cells and the β-amyloid deposits in the brain were assessed with Student's t test.
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We demonstrated that compared to hyperoxic CPB, normoxic CPB was associated with lower end-organ damage; cardiac, liver, and brain injuries were assessed with Tn-I, Alpha GST, and protein S100 and in all three cases were significantly reduced.
All patients presented with central nervous system symptoms and were assessed with brain MRI that demonstrated a lesion compatible with brain tumor.
All subjects underwent brain MRI (see below) and patients were assessed with the Mini Mental Status Examination (MMSE), a screening tool widely used for impaired cognitive skills [ 14].
In patients with Parkinson's disease with and without peak-of-dose LID, dynamic changes in striato-cortical connectivity were assessed with whole-brain functional MRI, while patients performed a simple motor task.
Bootstrap values were assessed with 1000 replicates.
Blood samples were taken and brain perfusion was assessed with near-infrared spectroscopy measuring (de)oxygenated hemoglobin [ 42].
Before the first and after the last rTMS-session brain activation was assessed with fNIRS while patients were performing a cognitive task.
The relationship between EV protein levels and WML volume (expressed as log transformed percentage of intracranial volume) and BPF (expressed percentage of intracranial volume) on 1.5 T brain MRI was assessed with multivariable linear regression modelling.
Leakage of the blood-brain barrer was assessed with bovine serum albumin coupled with Cy5.5 (BSA-Cy5.5)., which distributes very slowly from the blood into the interstitial space except for sites of inflammation, where the dye accumulates.
Each of these two stimuli generates an event-related brain potential that is assessed with electroencephalography (EEG).
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