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In summary, multiple testing corrections were applied at different levels: first, adjusting for testing multiple voxels in the whole brain was implemented using FWE correction; second, adjusting for testing multiple SNPs using Bonferroni correction, and finally, the gold standard of replication analysis was carried out to rule out any remaining false positive associations.
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Mild traumatic brain injury was implemented using a model of mild closed head injury (CHI) adapted from Prins et al. using an electromagnetic device (Impact One, Leica Biosystems, Buffalo Grove, IL) modified with a rubber tip manufactured by the Thomas Jefferson Machine Shop (Fig. 2) [23 25].
SVM [Vapnik, 1995] was implemented using PROBID (Pattern Recognition of Brain Image Data) software (http://www.brainmap.co.uk/probid.htm) version 1.04.
Cortical current density inverse imaging was implemented using a generic realistic geometry brain head model from scalp EEGs.
Differential expression analysis was implemented using edgeR50 version 3.16.5.
The GBLUP model was implemented using the R software94.
DGRP was implemented using MPI.
Communication between nodes was implemented using MPI [34].
KPP was implemented using PERL/CGI.
This method was implemented using SAS [ 33].
Each run was implemented using the colony.
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