In order to explore the condition of BBB in vivo, the experiments on ALS rat brain were conducted using 1.5T magnetic resonance imager with surface coil.
MR imaging of ex vivo brain samples was conducted using a 19 mm horizontal magnetic bore in a 7.0 Tesla Bruker Pharmascan with Paravision 4.0.
Inference of whole-brain statistical images was conducted using the general linear model and cluster-wise family-wise error rate control with p< 0.05 corrected for multiple comparisons.
Psychomotor vigilance testing was conducted using Brain Checkers software, Version 3.01 (Behavioral Neuroscience Systems LLC, Springfield, MO, USA) run on Palm Tungsten E2, (Palm Inc. Milpitas, CA, USA).
The estimation of brain optical properties from simulated data was conducted using the homogeneous FD-MD method described previously [ 9, 18].
A PubMed search, last update 24th of June 2013, was conducted using the terms "deep brain stimulation" and "obsessive compulsive disorder".
PubMed search, last update June 2013, was conducted using the terms "deep brain stimulation" and "obsessive compulsive disorder".
First, structural images were skull-stripped using the brain extraction tool (Smith, 2002) and tissue-type segmentation was conducted using FAST (Zhang et al., 2001).
Evaluation of labeling for c-Fos between neglectful and nurturing MaD1 mice was conducted using a one-way ANOVA for each brain region.
Ocular correction was conducted using the regression-based approach (Gratton et al., 1983) implemented in Brain Vision Analyzer 2.0 (Brain Products, Gilching, Germany).
