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All regional brain volume data were normalized to account for differences in absolute volume related to varying participant age.
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Brain volume data was unavailable for one patient with T2DM (due to a significant non-vascular abnormality on MRI) and technical difficulty rendered aortic reservoir data unavailable in two participants (one participant from each group), resulting in 37 participants in each group.
For comparison of developmental and adult brain scaling, brain volume and partition volume data were obtained from Pirlot54 for 27 marsupials (17 Australian and 9 American species).
We emphasize these points because the brain volume data examined in our study are from unsexed primate specimens (Additional files 1 and 2) [ 43].
Whole-brain rs-fMRI data were acquired using gradient echo-planar imaging to acquire T2*-weighted volumes with blood oxygen level-dependent (BOLD) contrast.
Regional volumes were preserved while corrections for global differences in whole brain volume were made.
Longitudinal volumetric MRI data suggest that ∼1.43% of the total brain volume may be lost following traumatic brain injury (Trivedi et al., 2007).
All brain volume outcome measures were expressed as a ratio of total intracranial volume.
Brain volume loss was determined using SIENA.
Many aspects of brain homeostasis, among which are measures of total brain volume, are highly heritable1.
Whole brain volume, regional volumes and cortical thickness measures (volumes normalized to ICV and raw cortical thickness data) were included in a recent study (McEvoy et al. 2011).
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