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Despite the intuitive appeal of a 'bigger is better'[ 11] association between brain volume and cognitive performance, structure-cognition associations, where they are found, are not easy to replicate, and are sensitive to the composition of the sample tested, and the cognitive tests used [ 12].
This study was designed to assess changes in brain volume and cognitive abilities in memantine-treated patients with Alzheimer's disease (AD) by using an exploratory, single-arm, delayed-start design.
Ageing affects both brain volume and cognitive ability in non-demented older people.
The association between brain volume and cognitive ability may be different in pathological cognitive impairment.
Secondary goals of the study were to test for associations between brain volume and cognitive test scores and between fight exposure and cognitive test scores.
Our findings of inverse relationships between fasting insulin levels, HOMA-IR, and brain volume and cognitive performance even after controlling for vascular risk factors— appear to support these findings.
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Correcting for education attenuated the relationship between brain volumes and cognitive tests (WBV and g r =.18, P =.08; ICA and g r =.18, P =.08.
Our study was not powered to look for sex differences, but emphasises the importance of consideration of sex when investigating brain volumes and cognitive ability.
Also, although all subjects scored > 24 on the MMSE, some may be in subclinical stages of dementia, which could affect both brain volumes and cognitive function.
The aim of this study is therefore to examine the interplay between education, regional brain volumes, and cognitive function, while assessing the extent to which CVD risk factors mediate these associations.
No significant bivariate associations were demonstrated between CVD risk factors and regional grey matter volumes (r s = −0.108, P = 0.196; n.s).. Overall, these findings justified the exploration of the associations between education, CVRF, regional brain volumes, and cognitive function in an SEM model in order to examine possible mediation mechanisms.
More suggestions(15)
brain volume and grey
brain volume and neocortical
brain volume and white
brain volume and many
brain volume and mean
brain volume and functional
brain damage and cognitive
brain volume and frontal
brain volume and hippocampal
brain volume and migratory
brain anatomy and cognitive
brain connectivity and cognitive
brain training and cognitive
brain volume and neurobehavioral
brain architecture and cognitive
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