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The difference in tumor to brain uptake was also verified by autoradiography, where the [131I]-I2-PARPi [131I]-I2-PARPi [131I]-I2-PARPin that in the healthy brain tissuptakeg. 8b).
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High pancreatic uptake was also seen.
In vitro, using the hCMEC/D3 human cerebral microvascular endothelial (CMEC) cell line, as well as primary bovine and porcine CMEC (and in contrast to non-brain derived endothelial and epithelial cells), we show that liposomal uptake occurs through the process of endocytosis and that the brain-specific uptake is also glutathione conjugation-dependent.
Brain uptake was expressed as standardized uptake value (SUV).
Brain uptake was low, but the cerebellum (the region with the highest density of mGluR1s) had a visibly, though slightly, greater uptake than the rest of the brain.
At baseline conditions, the guinea pigs showed distinguishable brain uptake compared to the surrounding tissue, whereas low brain uptake was observed in the rats and mice (Figure 1).
Although brain uptake was low, we wondered whether kinetic analysis of the brain and plasma data would suggest any specific binding in the brain.
The peak brain uptake was observed within a few minutes after the injection of [11C]HMS011.
Thus, the effect of blood sugar on brain uptake was not large [10].
Whole brain uptake was expressed as percent injected dose (%ID) (A).
However, no direct evidence on brain uptake was provided.
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