Sentence examples for brain uptake in both from inspiring English sources

In the present study, however, 11C-LY2428703 had low brain uptake in both humans and monkeys.

After CsA administration, the peak brain uptake in mice was at 1.5 min and at 1.2 min in rats.

The brain uptake in the ket/dex and dex are of intermediate magnitude, with up to 7 %ID/g in hippocampus and frontal cortex at 25 min.

We observed significantly higher brain uptake in baseline WT mice compared to S1R-KO mice at all time points during 60 min PET scan (P < 0.05).

This study is the first to report the impact of immune activation on oseltamivir brain uptake in living juvenile monkeys under therapeutic oseltamivir dosage.

The level of specific binding was determined by comparing brain uptake in the KOR-enriched striatum region, representing total binding, with the KOR-free cerebellum region, representing NSB.

One of the synthesized compounds, [11C]CW4, showed high brain uptake in rats and further evaluated in non-human primate (NHP) using PET-MR imaging.

TASP0390136 was also chosen for radiolabeling as a control compound with insufficient brain uptake in order to assess the consistency between ex vivo LC-MS/MS and in vivo PET data.

The major disadvantage of these compounds is their poor brain uptake in experimental animals (4.7% for 99mTc-ECD and 2.25% for 99mTc-HMPAO) (Walovitch et al. [1989]; Neirinckx et al. [1987]).

The IgG fusion proteins have been administered chronically in mouse models, and the immune response is low titer and has no effect on the fusion protein clearance from blood or brain uptake in vivo.

Specifically, we found that [19F]FTC-146 has only negligible in vitro affinity for VAChT compared to its picomolar S1R affinity (i.e., VAChT K i = 450 nM, S1R K i = 0.0025 nM) and that there is only negligible [18F]FTC-146 brain uptake in S1R-KO mice compared to age-matched WTs.