Ananthanarayanan, B., Kim, Y. & Kumar, S. Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform.
Stereotactic radiosurgery has been in use for several decades in treating brain tumors using a rigid frame fixed to the head to allow precise spatial positioning of target lesions.
In this work, a methodology is proposed to segment and classify the brain tumor using magnetic resonance images (MRI).
The distinction of MRS between recurrent tumor and radiation necrosis in brain tumor using the Cho/NAA ratio could be made with 85% sensitivity and 69% specificity [ 132].
For imaging of the mouse brain tumor using MALDI mass spectrometry, 10 primary human glioblastoma cells (NS276) were stereotactically injected into the right striatum of an 8-week old, NOD/SCID male mouse (Charles River Laboratories) as previously described.
Natalia, afflicted with a brain tumor, used her own birthday celebration in October to hand out soup and blankets at the Drop Inn Center for the homeless in Cincinnati.
He and colleagues evaluated 29 brain tumors using iCEUS but with some technical limitations: they used a phased array probe, with low frequency and a vast view-field, and the US imaging was performed in power Doppler modality instead of using a contrast specific algorithm, dramatically reducing both US spatial resolution and definition.
With colleague Nathalie Agar at Boston's Brigham and Women's Hospital, he already has demonstrated the feasibility of grading brain tumors using the lipid profiles they produce in a mass spectrometer (see "Mass Spec Imaging: From Bench to Bedside," scim.ag/1dCjmPx).ag/1dCjmPx
Though not specifically focused on treatment of GBM, there have been several attempts in nanoparticle-assisted laser ablation in animal models, including an orthotropic canine model examining brain tumors, using gold shells surrounding silica cores or "gold nanoshells".
