Four novel A-to-I editing sites on miRNAs, as well as another four A-to-I editing sites previously reported in brain tissues, are characterized in colon normal and/or cancerous tissues.
HD brain tissue is characterized by mutant protein aggregate formation and neuronal cell loss, with transcriptional deregulation as a prominent feature.
The resulting brain tumor tissue is characterized by pleiomorphic cells, continued proliferation and chromosome instability, as evidenced by a variety of karyotypic abnormalities [ 19].
They believed that long-term surviving brain tissues were in fact characterized by exclusive reactive astrogliosis or glial scarring, frequently lacking the initially formed blood vessels.
In addition to analyzing the glioma specimens, the expression profiles were also analyzed in normal brain tissue, and were characterized as absent, rare, moderate, and abundant, according to the expression intensities.
As the least well-conserved organ we identified the CNS; it is evident that CNS does not contain much connective tissue; furthermore, brain tissue is not characterized by specific substructures (with the exception of pigmented cells in the pigmented nuclei that may indeed be seen even in less well-preserved brain tissue specimens).
GBM induces reactive gliosis in surrounding brain tissues, which is characterized by morphological changes, increase in GFAP immunoreactivity and cellular distribution, besides the release of pro-inflammatory cytokines [ 22, 23].
Such unhindered flow is not possible in brain tissue that is characterized by a tortuous ECS with a normal volume fraction of ~20% [ 37- 39] which may be further decreased in ischemia due to cell swelling.
With these methods, the viscoelastic properties of brain tissue have been characterized, leading to a wide variety of data, however, with also a large variation between studies (Hrapko et al. 2008).
BCNU (carmustine), VM26 (teniposide) and ARA-A5'P (vidarabin-monophosphate) were compared in their activity against 30 cell lines of primary (N = 21) and metastatic (N = 9) human brain tumours, which were characterized in tissue culture by cytochemical, immunological and cytogenetic criteria.
