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Emamian and colleagues [24] demonstrated reduced AKT1 protein expression in B lymphoblasts and postmortem brain tissues from patients with schizophrenia.
We recently reported that the HIV-1 nef protein evolves differently in brain tissues from patients who develop HAD than from patients who do not [3].
Increased expression of C3 gene and protein, and activation of the complement system have been found in brain tissues from patients with mesial temporal lobe epilepsy (MTLE [15], [16] and from rodent MTLE model[17].
Brain tissues from patients and age-matched controls were analyzed for CAP37 expression using immunohistochemistry (IHC).
Brain tissues from patients with AD (n = 8) and normal controls (n = 8) were used (Table 1).
Formalin-fixed, paraffin-embedded brain tissues from patients with Alzheimer's disease and age-matched controls were sectioned at a thickness of 5 μm.
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To examine the histopathologic changes in HFRS patients, we used light microscopy to examine sections of formalin-fixed lung, liver, kidney, spleen, and brain tissues from patient no. 2, who had died of acute renal failure.
In a similar vein another part of the team is trying to reproduce seizures under laboratory conditions, working on brain tissue from patients who have undergone operations.
6. Rocca MA, Colombo B, Inglese M, Codella M, Comi G, Filippi M. A diffusion tensor magnetic resonance imaging study of brain tissue from patients with migraine.
Tests on brain tissue from patients who have died from PD found large amounts of iron in the substantia nigra, a region that deteriorates as the disease worsens.
When it comes to studying dementia you cannot simply take samples of brain tissue from patients to understand what is going on or to test treatments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com