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Data from glioblastoma tissues, normal skin, normal muscle, normal testis and normal brain tissues came from the series GSE15824, GSE7307 and GSE14905 and were all measured by hybridization with Affymetrix Human Genechips U133 plus 2.0.
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The samples of fresh human brain tissue come from patients who underwent epilepsy surgery because of a heterogeneous group of epilepsy etiologies such as tuberous sclerosis complex [ 17, 20, 21] and other malformations of cortical development [ 15– 17] and from patients with epilepsy of unknown etiology [ 15– 17, 20].
Working with human postmortem brain tissue comes with inherent limitations.
The contaminated tissue came from Cryolife Inc., the company in Kennesaw, Ga., that also supplied knee tissue later found to have infected the Minnesota man in November 2001.
In his second term Reagan imposed a moratorium on federal funding for research that utilized fetal tissue because such tissue came from terminated fetuses.
Unmatched normal breast tissue came from patients of good health.
Scar tissue comes from damage while stretching.
Three of the tissue types came from the brain, namely the prefrontal cortex, the visual cortex and the cerebellum.
Overall 94% of tissue assessed came from the primary.
However, our expression dataset is dominated by tissues which come from various parts of the brain and these show an idiosyncratic pattern of evolution.
Whose brain do they come from?
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