Here we review these methodological issues, and provide examples from our experiences using human arrays to examine brain tissue samples from squirrel monkeys.
Using a number of genomic analysis technologies, the research team conducted genomewide genetic (DNA) and gene expression (RNA) analyses of brain tissue samples from the prefrontal cortex.
Increased expression of NICD1, Hes1 and MMP9 was detected in brain tissue samples from patients with tuberculosis meningitis (Kapoor et al., 2010).
The project will also analyze existing brain tissue samples from Alzheimer's patients to validate biological targets, develop network models for late-onset Alzheimer's, and screen compounds against novel targets.
They treated brain tissue samples from a deceased patient with one of several anti-inflammatory drugs, then added a recently developed chemical marker called FDDNP, which glows when it binds to amyloid.
To verify that semaphorin 5A plays a role in autism, the researchers looked at brain tissue samples from the Autism Tissue Program and the Harvard Brain Bank and found the amount of the semaphorin 5A protein to be significantly reduced in autism brains compared to nonautism brains.
In the new study, the researchers analyzed postmortem brain tissue samples from eight people who had Alzheimer's disease and six people who did not have the condition.
In this study, brain tissue samples from animals naturally infected with BSE were analysed to identify differentially regulated genes using Affymetrix GeneChip Bovine Genome Arrays.
We have previously reported that elevated platform stress does not lead to a general modulation of GluA1 phosphorylation in brain tissue sampled from the entire frontal cortices [35].
Samples obtained from the CFIA, CDC and NYDOH were brain tissue samples from surveillance and rabies positive samples whereas samples obtained from OMNR and USDA-WS consisted of hair pulls from live trapped animals acquired during control programs, or muscle tissue.
