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SNCA-mRNA fold levels (SNCA/SYP) were measured in 228 brain tissue samples obtained from 144 subjects (83% white, 56.5% males; Table 1).
Brain tissues were collected from light-pulsed rats and compared to brain tissue samples obtained from control animals in darkness at ZT 15.
Rabies: Two brain tissue samples obtained from grey foxes (Urocyon cinereoargenteus) displaying symptoms of rabies were collected in Humboldt County, CA in March 2009 and December 2009 and tested for rabies virus via RT-PCR [ 35] using a modified protocol that amplifies a portion of the N gene.
Gene expression was examined in a series of post-mortem brain tissue samples obtained from 44 healthy individuals aged from 0 to 50 years of age with the aim of identifying genes whose expression levels were at their highest or lowest levels during late adolescence/early adulthood.
Injured brain tissue samples obtained from TBI patients requiring decompressive craniectomy for the treatment of life-threatening intracranial hypertension were found to have evidence of DNA fragmentation by TUNEL and cleavage of caspase-1 and -3, suggesting activation of caspase-dependent apoptosis [ 32].
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DB29 primary human glioma cells were established in our laboratory by culturing surgically removed brain tumour tissue samples obtained from the tissue repository at Methodist Research Institute with an IRB approved protocol.
Gene microarray analyses were performed on tissue samples obtained from various brain regions after a total of 11 days of ultrafine Mn oxide aerosol exposure (498 ± 69 μg/m).
An additional 12 DNA samples (2 RRMS and 10 controls) were isolated from tissue samples obtained from the Human Brain and Spinal Fluid Resource Center (VA Greater Los Angeles, CA).
The brain tissue samples were obtained from the 307 Hospital of PLA with the written informed consent of patients and with approval for experiments from the ethics committees of the hospital and the Beijing Institute of Biotechnology.
Fresh-frozen human brain tissue samples were obtained from the Netherlands Brain Bank, Amsterdam (NBB).
Human brain tissue samples were obtained from the New South Wales Tissue Resource Centre and the Sydney Brain Bank.
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