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The presence of full-length TU-1A has been demonstrated in human testis, liver, prostate, breast, and brain tissue, in human cancer cell lines derived from prostate (LNCaP) and breast (MCF-7), and in the testis of mice containing the 11-kb human SHBG transgene [5], [8].
While examining gene expression in brain tissue from subjects with psychiatric or neurological disorders might be more relevant to disease pathology, assessment of whole blood or lymphocyte gene expression has several advantages, including practical availability of blood compared to brain tissue in human subjects and reduced confounds such as post-mortem interval (PMI), pH and agonal factors.
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However, their local production is rapidly induced in response to acute hypoxia, as evidenced by the increased expression of EPO in cerebrospinal fluid (CSF) or postmortem brain tissue in humans with stroke and hypoxia [14, 15].
However, their local production is rapidly induced in response to acute hypoxia, as evidenced by the increased expression of EPO in cerebrospinal fluid (CSF) or postmortem brain tissue in humans with stroke and hypoxia [ 14, 15].
Additional file 4: Figure S3 separates the analysis for brain and non-brain tissues in human and mice.
Positron emission tomography using C-PK11195, a PBDZR ligand, was able to distinguish gliomas from normal brain tissue in in vivo human studies [ 10, 11].
Compounds 8b and 18c showed the highest affinity and antagonistic activity, within their series, towards the α2-adrenoceptor in human brain tissue in vitro experiments.
It is worth noting that the lack of CB2 receptors in the human brain microvascular endothelial cells isolated from human brain tissue in the present study is in contrast to previous studies.
Researchers in Japan thrilled the country's anthropologists last week with the news that they have found human brain tissue in three 1800-year-old 1800-year-old 1800-year-old skulls
JMcM is a senior postdoctoral researcher in the group, who has extensive experience in histological analysis of postmortem human brain tissue, in particular, that derived from patients with multiple sclerosis.
Regrettably, we do not have access to human HD brain tissue in sufficient quantity and quality to test the predictions of our analysis.
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