This gene is confirmed to be highly expressed in brain as shown in the tissue expression pattern created by WebGestalt with EST counts (Figure 9a) and the tissue expression levels seen with UniGene's EST ProfileViewer (Figure 9b).
In normal brain tissue the expression level of c-Met and DR5 is 0.45 and 2.4, respectively.
Compared with normal brain tissues, ACSVL3 expression levels are elevated in clinical GBM specimens and induced in GBM cells following the activation of oncogenic receptor tyrosine kinases.
By ELISA, brain tissue expressed the highest S100B levels.
Compared with control and normal brain tissues, the expression level of miR-494-3p miR-494-3p miR-494-3pegulated in glioma tissues (Fig. 1a, b).
Low basal MMP-9 expression occurs in normal brain tissue, but high expression levels are induced in glioblastomas, and are linked to increased tumour cell proliferation [ 29].
Even though our study is based on a single tissue, the coverage depth of our study allows identification of functional miRNA present in brain tissue at background expression levels.
In normal human brain tissue, the mRNA expression levels for centrosomal structural proteins, including centrin 3, γ-tubulin, and hNinein isoforms 1, 2, 5 and 6, was low; there was no detectable expression of Aurora A and Aurora B mRNA.
Within brain tissue, the highest expression level of DIA1R was in the cerebellar peduncles (Figure S3), a region of the brain abnormal in those with ASD [87] [89].
Its effects involved an equal antioxidant but better anti-inflammatory profile than resveratrol as shown by SOD2 expression in brain tissue and circulating levels of IL-6 (11 vs 18 pg/mL), respectively.
