Sentence examples for brain tissue due to from inspiring English sources

The thrombosis of the veins themselves causes venous infarction damage to brain tissue due to a congested and therefore insufficient blood supply.

However, the most serious impediment to pharmaceutical treatment is inefficient delivery of drugs to the disease-affected brain tissue, due to limitations and restrictions dictated by the existence of the blood-brain barrier (BBB) [1].

For instance, deletion of PKBα leads to a 30% reduction of body weight [26], [28], [34], while ablation of PKBγ specifically causes a significant reduction in brain tissue due to reduced cell number and size [29], [32].

Many therapeutic agents do not freely permeate into brain tissue due to the presence of the BBB and its associated P-gp efflux pump transporter.

A vast majority of bioactive agents do not readily permeate into the brain tissue due to the existence of the blood-brain barrier (BBB) and the associated P-glycoprotein efflux transporter.

The mechanism of the increased concentration of lactate in the CSF of patients with BM is not clear, but it has been linked with anaerobic glycolysis of brain tissue due to a decrease cerebral blood flow and oxygen uptake [ 66, 67].

This expectation is likely incorrect with respect to many brain tissues due to the differential maturation of key cell types.

Hence, the present solution may apply to a wide range of known physical phenomena with examples from biomechanics, as in the appearance of cavitation bubbles due to traumatic brain injury or expansion of soft tissue due to an internal growth, to fracture initiation in soft materials and softening of seismic bearings in large scale structures.

Since the child central nervous system might respond differently to TES (e.g., due to smaller distances between the scalp and the brain tissue, or due to differences in the organization of gyri and sulci), the potential physical side effects of TES cannot be entirely anticipated at this point.

10 Infection is likely related to prolonged steroid treatment and long hospitalization and subdural hematoma/hygroma related to pre-VPS brain tissue loss due to previous surgeries and RT.

To determine whether the effect of time of administration on the exposure to quinidine in brain tissue is due to variation in P-gp-mediated transport over the 24-h period, we administered the selective P-gp inhibitor tariquidar intravenously 30 min prior to quinidine administration at ZT0, 4, 8, 12, 16, or 20.