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The samples of fresh human brain tissue come from patients who underwent epilepsy surgery because of a heterogeneous group of epilepsy etiologies such as tuberous sclerosis complex [ 17, 20, 21] and other malformations of cortical development [ 15– 17] and from patients with epilepsy of unknown etiology [ 15– 17, 20].
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Data from glioblastoma tissues, normal skin, normal muscle, normal testis and normal brain tissues came from the series GSE15824, GSE7307 and GSE14905 and were all measured by hybridization with Affymetrix Human Genechips U133 plus 2.0.
Working with human postmortem brain tissue comes with inherent limitations.
Such tissue comes from elective abortions.
Unmatched normal breast tissue came from patients of good health.
Scar tissue comes from damage while stretching.
Whose brain do they come from?
However, our expression dataset is dominated by tissues which come from various parts of the brain and these show an idiosyncratic pattern of evolution.
Where did brains come from?
Three of the tissue types came from the brain, namely the prefrontal cortex, the visual cortex and the cerebellum.
We have examined the expression of COMT mRNA in brain tissue from patients with schizophrenia and from normal comparison subjects.
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