Analysis of PAD score was repeated for both GM and WM, and an exploratory analysis of the relationship between the 2 brain tissue classes was also carried out.
Based on random sampling, the number of brain samples in a data set was reduced while the samples in all other tissue classes were conserved.
The 19 main tissue classes are adrenal gland, brain, heart, kidney, liver, lung, lymph node, muscle, prostate, pancreas, placenta, salivary gland, thymus, thyroid, tonsil, testis, trachea, uterus, and uterine corpus.
For each individual, the time-courses of both WM and CSF were estimated in the relevant brain tissue classes defined at the segmentation step.
If brain tissue is available, it is sent to Dr. Gambetti, who can confirm the diagnosis.
All postmortem brain tissue used were randomized.
Fragments of the brain tissue were incubated with a PE-conjugated anti-class I antibody, which also stained the blood vessels quite brightly, whereas the surrounding brain tissue was largely unstained.
Hair and brain tissue were eliminated.
At present, brain tissue samples are owned by the researchers or organizations collecting the tissue or doing the science.
