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Additionally, at very early sub-threshold depression levels, abnormal changes in several neuronal populations are already detectable in HD patients, suggesting that a variety of brain structures may be involved.
However, beyond the dura mater and the trigeminovascular pain pathway (topics of other reviews within this special issue, and also reviewed recently [133]), PACAP-regulated neuro-inflammatory mechanisms within deeper brain structures may be involved in mediating these dural changes, such as in the brainstem, cortex, or autonomic projections, which lead to trigeminovascular activation.
It may be hypothesized that timing functions may be deteriorated to a different extent in motor and non-motor timing, because in motor timing the underlying brain structures may be more demanding than in non-motor timing.
The synthesis of proinflammatory cytokines in brain structures may be also stimulated and controlled by the same cytokines originating from the periphery or produced by the circumventricular organs and choroid plexus.
Therefore, modulation of resonance in different brain structures may be instrumental in enabling the development of coherent oscillations and ensuring reciprocal communication channels among different processing modules (Fries 2005; Montgomery and Buzsáki 2007).
Future work employing bioluminescence imaging of these brain structures may be able to resolve this, although use of this technology may be difficult given that neural tissues can be reset by the dissection procedure itself [ 31, 32].
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They also fail to state that changes in brain structure may be why medicines work, not a sign of a problem.
The altered brain structure may be indicative of functional and behavioural changes in the KD offspring.
Because the effect of age on brain structure may be non-linear and may also vary between individuals, matching by mean values alone might not be able to fully control for age effects.
Furthermore, apart from temporal contrast, we know relatively little about how the R-LMC-R system contributes in transmitting other features in the natural scenes, such as colour, line elements, orientation or motion, to the fly brain, or how the same network structures may be used for different processing tasks simultaneously.
There is increasing evidence that posterior brain regions are relatively more affected in EOAD and medial temporal lobe structures may be less involved [ 19, 21– 26, 26].
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