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Also, to our knowledge, none have related abnormal functional organisation to brain structural abnormalities in SLI.
The ALE method has also been used to investigate brain structural abnormalities in schizophrenia derived from studies using voxel-based morpometry analyses [ 1, 93].
Brain structural abnormalities in neonates are readily detected with MRI, and studies have reported that infants born <30 weeks' GA have grey and white matter abnormalities [ 14], white matter microstructural alterations [ 15], deficits in brain connectivity [ 16], and volume reductions in other brain regions and structures [ 17- 19].
In the context of scant extant studies examining the impact of glutamatergic genetic signals on brain structural abnormalities in BD, we aimed to investigate the relationship of GRIN2B gene and brain white matter (WM) changes in patients with BD using diffusion tensor imaging.
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The most consistent brain structural abnormality in patients with schizophrenia is enlarged lateral ventricles.
However, it is possible that the brain structural abnormalities observed in schizophrenia are not only due to neurodevelopmental anomalies, but also to an alteration in cortical plasticity and maturation processes that occurs over the long course of the disease.
Over 50% of individuals with alcohol use disorders (AUD) also use other substances; brain structural abnormalities observed in alcohol dependent individuals may not be entirely related to alcohol consumption.
There is substantial evidence that cognitive deficits and brain structural abnormalities are present in patients with Bipolar Disorder (BD) and in their first-degree relatives.
Background: Previous reports indicate that brain structural abnormalities may be progressive in some patients with schizophrenia.
Changes in the adolescent brain are structural (abnormalities in the cerebellum, amygdala, left hippocampus and white matter integrity) and functional (poorer processing time, decreased executive functioning and attention span).
Histological studies (Hematoxylin-Eosin, Masson's Trichrome, Sudan Black B and Picrosirius Red stains) of liver, heart, kidney, lung and brain showed no tissue structural abnormalities in G28UCM-treated animals when compared with control animals (data not shown).
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