To kick-start the project, the president allocated about $100 million this year to BRAIN, spread over the National Institutes of Health (NIH), the National Science Foundation, and the Defense Advanced Research Projects Agency.
Challenges also exist for the proposed "gut to brain" spread of Lewy pathology.
Lewy body related α-synucleinopathy (LBAS, the abnormal accumulation of pathologic α-synuclein) in the brain spreads in a sequential, predictable fashion, that is, it spreads rostrally from the brainstem in a process described by the Braak hypothesis [ 16, 17].
Misfolded synuclein fibrils injected focally into rodent brains spread to neuronally connected but not adjacent areas (Luk et al., 2012; Masuda-Suzukake et al., 2013) (see also Figure 1 figure supplement 3).
The virus penetrates the trigeminal nerve and subsequently the ipsilateral side of the brain stem, spreading there in contralateral and anterior direction.
Fluorescent tracers injected into the striatum of the mouse brain initially spread diffusely through the brain parenchyma, but within 5 minutes, the tracers are located in the capillary basement membranes and in the basement membranes around smooth muscle cells in the tunica media of arteries [ 3].
In OVA-sensitized mice, intracerebral injection of OVA resulted in the accumulation of OVA and IgG in the brain; the effect was restricted to the injected hemisphere of the brain although spread over the dorsal half (Fig. 1a, b).
That a cockroach can live without its head for several weeks because its brain is spread throughout its body?
A terminal brain tumor spread to her spine, causing such agony that eventually even morphine could not relieve it.
This occurs, I should add, as a sheet of roiling flame, known as brain fire, spreads over the ceiling, reaching a temperature of 3,400 degrees.
Some nasal tumours arise from the mucous membrane that lines the nose; others originate in the brain and spread to the nose.
