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To kick-start the project, the president allocated about $100 million this year to BRAIN, spread over the National Institutes of Health (NIH), the National Science Foundation, and the Defense Advanced Research Projects Agency.
Challenges also exist for the proposed "gut to brain" spread of Lewy pathology.
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Lewy body related α-synucleinopathy (LBAS, the abnormal accumulation of pathologic α-synuclein) in the brain spreads in a sequential, predictable fashion, that is, it spreads rostrally from the brainstem in a process described by the Braak hypothesis [ 16, 17].
Misfolded synuclein fibrils injected focally into rodent brains spread to neuronally connected but not adjacent areas (Luk et al., 2012; Masuda-Suzukake et al., 2013) (see also Figure 1 figure supplement 3).
A terminal brain tumor spread to her spine, causing such agony that eventually even morphine could not relieve it.
That a cockroach can live without its head for several weeks because its brain is spread throughout its body?
Some nasal tumours arise from the mucous membrane that lines the nose; others originate in the brain and spread to the nose.
The data suggest that fibrils in the brain may spread from a single nucleation site, that structural variations may correlate with variations in AD, and that structure-specific amyloid imaging agents may be an important future goal.
But now we know that as the disease's brain changes spread, other circuits are also impacted, causing symptoms like depression, anxiety, sleep disturbances and cognitive issues.
Then, as the wave of blood-starved brain cells spread out, our memories and language centres short out, until we're left with just a core.
Indeed, VN/1203 virus injected intravenously or into the brain can spread to the lungs [23].
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