Sentence examples for brain shuttle from inspiring English sources

The Brain Shuttle (BS) technology is capable of shuttling large molecules into the brain.

Enhanced target engagement of the Brain Shuttle module translates into a significant improvement in amyloid reduction.

Brain Shuttle version of an anti-Aβ antibody, which uses a monovalent binding mode to the TfR, increases β-Amyloid target engagement in a mouse model of Alzheimer's disease by 55-fold compared to the parent antibody.

We report that by manipulating the binding mode of an antibody fragment to the transferrin receptor (TfR), we have developed a Brain Shuttle module, which can be engineered into a standard therapeutic antibody for successful BBB transcytosis.

Similarly, diketopiperazine-based motif is considered as a novel brain shuttle for the delivery of drugs with limited ability to cross the blood brain barrier [ 225, 234].

We present the Brain Shuttle-mAb (BS-mAb) technology, and we investigate the role of Fc effector function in vitro and in an Fcγ receptor (FcγR -humanized mouse model.

In the normal brain, serotonin shuttled between mood-maintaining neurons, signaling their appropriate function.

These ultracompliant PDMS implants have been inserted into the brain using a shuttle with a charged self-assembled monolayer.

In contrast to ubiquitous class I HDACs, HDAC4 as a class IIa family member is restricted to certain tissues, including the brain, and can shuttle between the cytoplasm and the nucleus.

My lower legs are exactly appropriate to their function, which is to help shuttle my brain around as it tends to its daily chores.

Ca2+ activates this shuttle in brain mitochondria (K0.5 = 0.3 μM) [52].