Images of the relevant brain sections from each individual were taken with a digital camera (Leica DFC320, Solms, Germany) connected to a stereomicroscope (Leica M, Leica IM 50, Solms, Germany).
Post-mortem analyses of brain sections from AD patients revealed variable plaque size in individuals.
To further investigate the ability of THK523 to recognize tau lesions, we undertook immunohistochemical and fluorescence studies in serial brain sections taken from individuals with AD (n = 3), CBD (n = 2), PSP (n = 1), PiD (n = 2) and Parkinson's disease (PD; n = 2).
TP53BP1S25* was also detected in syncytia present in the lymph nodes or frontal brain sections from HIV-1-infected carriers, as well as in peripheral blood mononuclear cells from HIV-1-infected individuals, correlating with viral load.
Entire brain sections from mice containing orthotopic brain tumors injected intravenously with nanoparticles were imaged using both optical microscopy to identify the brain tumor, and scanning electron microscopy to identify the individual nanoparticles.
In vivo immunohistochemical analysis demonstrated little caspase-9 activation in the majority of hippocampal brain sections from control brains.
b Autoradiography and H&E stains of ex vivo brain sections from orthotopic U251 MG brain tumor mice.
In addition, immunohistological evaluation of brain sections from PML patients showed a marked decrease in the level of SF2/ASF expression when compared to normal brain sections (Fig. S2).
Sections were inspected through a microscope and the areas of damage plotted on drawings of brain sections from a rhesus monkey brain atlas (Szwarcbart, 2005).
