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SPECT brain scans were acquired on 21 cocaine dependent subjects and 21 healthy matched controls.
T1-weighted volumetric MRI brain scans were acquired on a 3.0 T Siemens TIM Trio scanner using a magnetization prepared rapid gradient echo sequence with a 28.2 cm field-of-view to provide 208 contiguous 1.1 mm thick slices.
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An FDG brain scan was acquired on a Siemens Biograph mMR PET-MR scanner.
First, a T1-weighted whole brain scan was acquired for anatomical reference.
In addition, a high-resolution, T1-weighted, inversion-prepared three-dimensional magnetization-prepared rapid gradient echo (MPRAGE) whole brain scan was acquired for each study participant.
> -wrap-foot> Brain MRI scans were acquired in all subjects on a 1.5 T GE Signa scanner (General Electric, Milwaukee, WI).
At the end of the functional runs, whole-brain structural scans were acquired using a Modified Driven Equilibrium Fourier Transform sequence.
Whole-brain structural scans were acquired using a Modified Driven Equilibrium Fourier Transform (MDEFT) sequence (Ugurbil et al., 1993) with optimized parameters as described in the literature (Deichmann, Schwarzbauer, & Turner, 2004).
In order to improve signal-to-noise ratio, eliminate movement artefacts, and thus to obtain at better representation of the actual brain, two consecutive scans were acquired.
Whole brain 3D T1-weighted scans were acquired using a sagittal MP-RAGE acquisition (inversion time: 900 ms, repetition time/echo time/flip angle: 2300 ms/4.18 ms/9°, one average, voxel size: 1 × 1 × 1 mm).
High-resolution gradient-echo multislice T1-weighted scans, coplanar with the EPIs, as well as whole-brain MP Flash 3-dimensional T1-weighted scans were acquired for anatomical localization.
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